The formulation platforms at 2Y-Chem support R&D for oral solid, oral solution, semi-solid topical/transdermal and injectable dosages. Our talented team is experienced in developing sustained/controlled release system, and formulations for low solubility compounds.

Drug Product R&D Services

Pre-formulation studies:
    • pH-solubility profile
    • Solid state and solution stability
    • Intrinsic dissolution rate assessment
    • Excipient compatibility screening
    • Moisture adsorption/desorption
    • Crystallinity evaluation
    • Material flowability tests

Formulation Development:
    • Alignment of TPP and QTPP
    • Prototype formulation design and screening
    • Formulation optimization
    • Formula robustness evaluation
    • Solubility/Dissolution enhancement
    • API micronization
    • Amorphous solid dispersion
    • Immediate release tablet/capsule/granule/powder formulations
    • Sustained/controlled release tablet/capsule/pellet formulations
    • Orally disintegrating tablet/sublingual tablet
    • Semi-solid cream, gel, ointment, emulsion formulations

Primary Package Development
    • Package development for moisture/oxidation sensitive APIs